منابع مشابه
Antimycobacterial activities of novel levofloxacin analogues.
In order to investigate structure-activity relationships between antimycobacterial activities and basic substituents at the C-10 position of levofloxacin (LVFX), we synthesized a series of pyridobenzoxazine derivatives by replacement of the N-methylpiperazinyl group of LVFX with various basic substituents. A compound with a 3-aminopyrrolidinyl group had one-half the activity of LVFX against Myc...
متن کاملNovel Levofloxacin Derivatives as Potent Antibacterial Agents
In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synth...
متن کاملLevofloxacin and Ceftriaxone in Combination
21 Objectives: Whether synergistic antimicrobial combination in vitro would be beneficial in 22 down regulation of pneumococcal virulent genes and associated inflammation of the lung 23 tissue induced by multi-drug resistant S. pneumoniae infection in vivo needs to be elucidated 24 for considering this mode of therapy in case of severe pneumococcal infection. 25 Methods: We investigated the in ...
متن کاملA Case of Levofloxacin-Induced Hepatotoxicity
BACKGROUND Levofloxacin covers a broad spectrum of pathogens and is readily prescribed by clinicians. Hepatotoxicity is a known but unusual complication of levofloxacin use. Here, we present a case of severe transaminitis caused by levofloxacin. CASE REPORT A young man in his thirties with a history of asthma, chronic alcoholism, methamphetamine intravenous drug abuse (IVDA), and non-compliant in...
متن کاملTreatment of pulmonary actinomycosis with levofloxacin.
Actinomycosis is a chronic suppurative bacterial infection characterized by multiple abscesses, fistulous pathways, and fibrosis involving the face, neck, chest, and abdomen. It is caused by an anaerobic Gram-positive saprophytic bacterium (Actinomyces). Primary actinomycosis of the lung is a rare disease that probably results from aspiration of oropharyngeal secretions. It can present as a chr...
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ژورنال
عنوان ژورنال: Journal of Marine Medical Society
سال: 2020
ISSN: 0975-3605
DOI: 10.4103/jmms.jmms_72_19